Present in some still lifes, including vanities, skull symbolizes the destructive time and the vanity of all human attachment to things perishable. It may also be the attribute of melancholy or connote repentance, meditation and preparation for death (memento mori). It is the attribute of Mary Magdalene in the representations of Mary Magdalene Penitent. But the skull also appears at the foot of Jesus' death on the cross (on Mount Calvary, Golgotha) in reference to sin after he had bought the Christian tradition, that of Adam, which would be the skull.
The skull and crossbones accompanied by the emblem of piracy. It is also an icon that serves as a warning to be dangerous, such as a toxic product.